Congenital hypothyroidism
Child < 1 yr: 25-50 mcg PO qd, increase to 50 mcg in 4-6 wk. For pts with CV disease, adjust dose.
Hypothyroidism
Infant < 6 month: 25-50 mcg or 8-10 mcg/kg/day.
Infant 6-12 month: 50-75 mcg or 6-8 mcg/kg/day.
Child 1-5 yr: 75-100 mcg or 5-6 mcg/kg/day.
Child 6-12 yr: 100-150 mcg or 4-5 mcg/kg/day.
Child > 12 yr: 150 mcg or 2-3 mcg/kg/day.
Adult: Mild hypothyroidism: 50 mcg PO qd, increase by 25-50 mcg q PO qd 2-4 wk until response; give IV< IM prn. Severe hypothyroidism: 12.5-25 mcg qd, in by 25-50 mcg qd q 2-4 wk until response. For pts with CV disease, adjust dose.
Myxedema coma
Adult: 300-500 mcg IV. If no response in 24 h, 100-300 mcg IV in 48 h. Maintenance dose 50-200 mcg until pt stabilizes and drug can be given PO. For pts with CV disease, adjust dose. |